|
|
Build Your Online Product Catalogs?
| Product Name: |
Nootropic Supplement Donepezil/nootropic@ycgmp.com
|
| Supply Ability: |
500kg/month |
| Related proudcts |
donepezil, |
| Specifications |
99% |
| Price Term: |
CNF |
| Port of loading: |
HK/Shanghai/Shenzhen |
| Minimum Order |
5g |
| Unit Price: |
$1 |
|
Donepezil
Product Name: Donepezil
CAS: 120014-06-4
MF: C24H29NO3
MW: 379.492
Purity: 99%
MP: 207â„?
BP: 527.9°C at 760 mmHg
FP: 273.1°C
Density: 1.141g/cm3
Grade: Pharmaceutical Grade
Appearance: White Powder
Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of Alzheimer's disease. Common side effects include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a biological half-life of about 70 hours, it can be taken once a day.
Function
Donepezil has been tested in other cognitive disorders including Lewy body dementia and vascular dementia, but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer's patients. Donepezil has also been studied in patients with Mild Cognitive I***irment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive i***irment, cognitive i***irment associated with multiple sclerosis, CADASIL, and Down syndrome.
A 3 year NIH trial in patients with mild cognitive i***irment reported that donepezil was superior to placebo in delaying rate of progression to dementia during the initial 18 months of the study but this was not sustained at 36 months. In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. However at this time donepezil is not indicated for prevention of dementia.
Recent studies suggest that Donepezil can improve speech in children with autism. The studies found that speech of autistic children who were mild to moderately affected appeared to improve from the use of Donepezil.
Mechanism of Action
Donepezil binds and reversibly inactivates the cholinesterases, thus inhibiting hydrolysis of acetylcholine. This results in an increased acetylcholine concentrations at cholinergic synapses.
The precise mechanism of action of donep |
| Company: |
Hangzhou Fuluo Biological Technology Co.,Ltd
|
| Contact: |
Ms. Cindy Lee |
| Address: |
4#Xinfeng Road,Hongjie Street,Jianggan District |
| Postcode: |
310017 |
| Tel: |
86-0571-87963072 |
| Fax: |
86-0571-87963072 |
| E-mail: |
|
|
|
|
Home
